Spastic tetraparesis occurred in a girl immediately after the vaccination of DTP when Symbat was 6 months old.
Before this vaccine, Symbat could:
knead the dough;
direct a hand to the toy, from whatever side it is;
roll over from abdomen to back;
hold a toy in each hand;
the girl crawled, sat down, lay down and got up on her own.
Sabina's parturition was planned, the girl screamed as soon as she was born. The child had no any problems. At 6 months, the pediatrician at the polyclinic at the place of residence appointed Symbat to undergo routine DTP vaccination. The day after the vaccination, Symbat could no longer sit. The girls' hands have become "naughty." The child could not hold anything in the hands.
In the neurological department of the hospital in Bishkek, where Sabina addressed with Symbat, the doctors assured that they knew these complications and that after four days, the girl's movements recovered and she could again sit and crawl. The next day, the condition of Symbat became even worse. The movements of the arms and legs are gone. From a cheerful, healthy girl, the Symbat has turned into a motionless "zucchini".
On the third day, the hands of motionless Symbat wound up and twirled behind the body by themselves. Unable to hold out for four days, Sabina addressed to the same hospital, to the same neurological department, to the same doctors. Doctors began to see that the girl has progressing a lightning-like form of spastic palsy. Doctors began to say that Symbat was born this way, with muscle spasticity and hands twisted back. Sabina had to prove to the doctors in the hospital that Symbat was born healthy. To do this, Sabina was forced to go to the maternity hospital where Symbat was born.
After a midwife from a maternity hospital confirmed that the baby was born healthy, they received the diagnosis: post-vaccination double hemiplegia (spastic tetraparesis), cerebral paralysis.
In the neurological department of the Bishkek hospital, where Symbat was hospitalized, doctors (I would write: bad doctors), gave her intensive treatment. What exactly was treated, I do not know. But Sabina says they gave her child 12 pills a day! And three injections per day were injected into a small six-month-old baby! The result of this treatment: general poisoning of a small defenseless organism with persistent diarrhea. The same doctors make a diagnosis: enterocolitis!
But the worst thing is that at this very time, Symbat threw her head back and her body twisted like a corkscrew opening the cork from a bottle of wine. These are the physical sufferings of a little six-month-old girl who just played a week ago, laughed, crawled, and was happy with her mom and dad!
Sabina addressed for help to doctors with one diagnosis. As a result of the treatment carried out by the doctors, little Symbat has already received two diagnoses and a heavy deterioration of her condition.
Before going to the doctors, Symbat weighed 10 kg with a height of 76 cm. As a result of the help that Symbat was provided by the doctors, the girl began to weigh 8 kg and could not gain weight for another year and a half. Not a month and a half, but a year and a half!
By the time of addressing to me (Nikolai Borisovich Nikonov), Symbat weighed the same 8 kg. When Sabina turned to me, Symbat did not hold her head, tilted it back with a constant twist on its side, the torso was arched with a crescent and twisted like a corkscrew, the handles stretched back and not naturally turned out. The child does not sit, does not crawl.
Sabina and Rahat asked me to give them my knowledge, skills and experience so that they themselves could recuperate their daughter.
After the first consultation, Symbat for the first time, after the vaccination, became soft. Muscle spasticity has decreased many times. I gave my knowledge, skills and abilities to Sabina and Rahat. Symbat will be recuperated soon!
Symbat before DPT vaccination
Consultation with Dr. Nikonov
Symbat after emendic procedures
How do I feel about DPT vaccination in children with cerebral paralysis
There is no definite answer. I watched all the speeches of the Chief Medical Officer of Russia, Anna Popova, who speaks of vaccination with all vaccines, except for the DPT vaccine. Former Chief Medical Officer of Russia Gennady Onishchenko also spoke about vaccination with all sorts of vaccines, except for the DPT vaccine. Even Russian President Vladimir Putin is talking about vaccination, but at the same time, he is not talking about DPT vaccine. Why? Can it be because of a lot of irreparable complications after DPT vaccination?
There is a Federal Law as of November 21, 2011 "On the basis of protecting the health of citizens of the Russian Federation", where the article in clause 5 says that any citizen of the Russian Federation may refuse medical assistance from the government.
Each person is always facing a choice:
If parents decided to vaccinate their child with DTP, and there will be serious complications after vaccination, are parents morally and financially ready to help their child? In this case, a person may demand compensation from the government on the basis of the Federal Law as of September 17, 1998 N 157-FZ (as amended on December 31, 2014, with amendedments on December 12, 2016) “On Immune Prophylaxis of Infectious Diseases”.
Article 18. The right of citizens to social support in case of post-vaccination complications, i.e.
In the event of post-vaccination complications, citizens are entitled to receive state lump-sum benefits, monthly monetary compensation, temporary disability benefits.
Financial support for the payment of state lump-sum benefits and monthly monetary compensation are expenditure obligation of the Russian Federation.
The Russian Federation delegates to the state authorities of the constituent entities of the Russian Federation the exercise of the rights of citizens to social support for the payment of state lump-sum benefits and monthly monetary compensation in the event of post-vaccination complications.
If a person does not take a DPT vaccine, is he ready for the fact that his child can get sick with pertussis, diphtheria or tetanus? Or a child can live a life and not get sick with these diseases. After all, we do not live in Africa. Pertussis, diphtheria and tetanus are serious diseases in the classic manifestation. They carried death in the 20th century before the emergence of strong antibiotics and toxoids. Modern medicine of the 21st century is able to cope with these diseases.
Neurologists consider cerebral paralysis a neurological disease, so vaccinations can be canceled for medical reasons. I believe that a child with cerebral paralysis is healthy from the point of view of neurology, but I support withdrawal from vaccinations for medical reasons.
As the muscles: a child with cerebral paralysis is disabled, in translation - motionless.
From the point of view of the Nobel Laureates of 2016 and 2017, there is a lot of unnecessary protein in the muscle cells of children with this diagnosis, from which the muscle cell cannot get rid of itself and therefore does not move. During vaccination, doses of a protein foreign to the child’s body are injected, which get inside the muscle cell and accumulate there. Because of this, the child's muscles stop moving and a state similar to tetraparesis occurs.
From the point of view of the infectious disease physician (I also had such an improvement), the protein contained in the DTP vaccine ensures the safety of the child’s body when it encounters real live bacteria of pertussis, diphtheria and tetanus.
The question arises: under what conditions does a sedentary child meet these bacteria in life?
DPT vaccine is a biological product that contains:
Bacterium Bordella pertussis protein;
Bacterium Corynebacterium diphtheriae protein;
Bacterium Clostridium tetani protein.
After the introduction of this biological drug (vaccine), the child’s body is forced to defend against this protein and produce an immune-response protein. When the body produces an immune-response protein more than necessary, its surplus is concentrated in muscle cells. Because of this, the muscle cell cannot move.
So like that spastic tetraparesis in children after vaccination occurs! So got sick Symbat.
Preservatives: antibiotics, mercury, phenol. Substances that can affect the body in such a way that it has to produce a large amount of protein in order to clear itself of aluminum hydroxide. The protein produced by the immune system accumulates in muscle cells and reduces its motor ability.
Modern pertussis differs from whooping cough of the last century by milder course and faster recovery. Let's consider the classic pertussis, which was in the 20th century.
Pertussis occurs in both vaccinated and non-vaccinated children, but due to antibiotic treatment, has not typical clinical symptoms. Pertussis is caused by a specific bacterium called Bordetella pertussis.
The microbe is transmitted by airborne droplets (when coughing, sneezing, talking) with close contact with a sick person. The disease is very contagious. Contact (for example, through toys) transmission of infection is impossible, because the bacteria quickly dies in the external environment.
The gates for infection is the mucosa of the respiratory tract. Pertussis microbes attach to cells of the ciliated epithelium, where they multiply on the surface of the mucous membrane, without penetrating the bloodstream. At the site of Bordetella pertussis attachment, an inflammatory process develops, the activity of the ciliary apparatus of epithelium cells is inhibited, and the secretion of very viscous mucus increases.
The epithelium of the respiratory tract ulcers and focal necrosis occurs. Ulcerations are most obvious in the bronchi and bronchioles, less obvious changes develop in the trachea, larynx and nasopharynx. Muco-purulent corks clog the lumen of the small bronchi, focal atelectasis, emphysema develops.
The persistent discharge of viscous mucus causes coughing. A cough is needed by the body to clear the airways from viscous mucus, which clogs the bronchi.
Because of bronchial obstruction with mucus, children died at the beginning of the last century. The transferred pertussis (as well as the DPT vaccine) does not provide intense lifelong immunity; therefore, whooping cough is possible in children who have been vaccinated as well as in those who have had pertussis.
Innate immunity due to maternal antibodies does not develop. If the mother suffered pertussis, like a disease, or made vaccinations, the child's body does not know about it. The probability of infection in contact with people with pertussis is 90%. Since, before the appearance of a characteristic cough, it is difficult to distinguish pertussis from other infections, pertussis patients have time to infect their environment during the first week of the disease.
Pertussis symptoms in vaccinated and unvaccinated children
The incubation period lasts from 2 to 14 days. The catarrhal period is characterized by general malaise, a slight cough, runny nose, low-grade fever, and often passes from the doctors as colds.
Gradually, the cough increases, children become very irritable, capricious. At the end of the 2nd week of pertussis development, a period of spasmodic cough begins. A cough in a sick child is specific, I would call it a barking. I was lucky that I saw children with the classic form of pertussis. Therefore, I describe my observations.
Attacks of convulsive cough begin suddenly, manifest by a series of cough tremors, due to the fact that the mucus is very viscous and it is impossible to cough up from the first or second time. Then follows a deep whistling breath - a reprise, followed again by a series of short, convulsive barking shocks of cough. The number of such cycles during an attack varies from 2 to 15 and depends on whether the child has coughed up mucus or not. Coughing attacks end with viscous vitreous mucus, sometimes vomiting occurs at the end of the attack.
During the attack, the child is excited. The face of the baby gets bluish color, neck veins dilate. The child's eyes may be covered with blood, the tongue may protrude from the mouth. Since the frenulum of the tongue is often injured, blood vessels may burst and drops of blood may appear. If the viscous mucus does not cough up, then respiratory arrest with the development of asphyxiation may occur.
The duration of attacks of pertussis on average is 4 minutes. During the day, the number of coughing attacks can be from 5 to 50. The period of convulsive barking pertussis cough lasts for 3-4 weeks, then the attacks become less frequent and finally disappear, although the “usual” cough lasts for another 2-3 weeks (the resolution period).
Abraded forms of pertussis can be observed in vaccinated children, they infect other children, and no one even guesses about it.
Complications of pertussis: pneumonia. In adults, complications are rare.
The clinical presentation of diphtheria of the 19th and 20th centuries differs from the modern form of diphtheria in its more severe course. But on my website I will write a clinical picture, namely, a severe form of the disease.
Diphtheria is an acute, life-threatening infectious disease. It occurs in the form of acute inflammation of the upper respiratory tract, mainly the pharynx (approximately 90% of cases), the nose, the skin where it is damaged, the eyes or genital organs. The main threat, however, is not inflammation, but poisoning with a toxin, which is produced by the bacterium - the causative agent of the disease, and cardiovascular and nervous systems are mainly affected.
Diphtheria pathogen and routes of infection
The causative agent of diphtheria are Corynebacterium diphteriae - gram-positive bacteria in the form of sticks with characteristic flask-shaped bulges at the ends.
When I looked in the microscope, I saw bacteria in the form of sticks with flask-shaped bulges at the ends. These bacteria were arranged in pairs, at an angle in the form of a Roman numeral V with respect to each other.
Diphtheria sticks in the process of life produce diphtheria toxin and the enzyme neuraminidase. Studying biochemistry, I learned that the synthesis of diphtheria toxin by diphtheria bacteria is controlled by a special gene. The disease is transmitted by airborne droplets from patients or from healthy carriers of the infection.
The airborne path is talking, coughing, sneezing. During a conversation, steam is released from the mouth of a sick person. This steam consists of the smallest droplets of saliva. In these droplets of saliva, diphtheria bacteria are in a live state. If this droplet of saliva with live bacteria gets inside the interlocutor during his inhalation, then the diphtheria bacterium begins to live and multiply in another person. If a droplet of bacteria has had time to dry, then diphtheria bacteria die instantly.
Children 3–7 years old are most susceptible to diphtheria, but in recent years the incidence among of adolescents and adults has increased. The source of infection is sick people or healthy carriers of toxigenic bacteria that have been vaccinated.
Diphtheria of the pharynx, nose, and larynx are most infectious, since patients actively excrete pathogens of the disease with exhaled air. Healthy carriers of bacteria are much less contagious, but the lack of any external signs of their condition does not allow them to control the spread of their infection, because they can only be detected by chance during mass clinical examinations.
As a result, most cases of diphtheria infection are due to contact with healthy carriers of diphtheria. The incubation period (the time from the moment of infection until the first signs of the disease appear) is 2–10 days.
Let's turn again to biochemistry: poison (toxin), produced by diphtheria bacillus, consists of its own poison and two enzymes hyaluronidase and thrombokinase. These three components act in the child's body together, helping each other.
Hyaluronidase destroys the hyaluronic acid of capillary muscle cells. Some muscle cells die by necrosis. In the capillaries small holes are formed and the capillaries become to be similar to a sieve. Blood plasma begins to flow out of these vessels through these holes. Fibrinogen protein is deposited from the blood plasma from the outside of small capillaries. Diphtheria toxin (poison) destroys epithelial cells with the release of the enzyme thrombokinase from them. Thrombokinase converts fibrinogen, which was formed from plasma flowing from capillaries, into fibrin. This forms a fibrin film.
The action of diphtheria toxin on the palatine tonsils, which are covered with several layers of epithelial cells, forms a fibrin film that penetrates deep into the epithelium of the tonsils and is tightly welded to it.
Symptoms and course
Usually, the disease begins with a slight increase in body temperature, mild pain when swallowing, redness and swelling of the tonsils. A specific filmy plaque is formed on them, which is accompanied by an increase in the anterior upper cervical lymph nodes. The color of the tonsil films is usually white in the first 2–3 days of the disease, but as the disease progresses, it becomes gray or yellowish gray. In a week, the disease either ends in recovery (the milder form, as a rule, in those vaccinated against diphtheria), or goes into a more severe toxic form, due to the systemic action of diphtheria toxin.
It flows hard enough. The disease is characterized by a high body temperature of the patient (within 39.5 - 41.0°С), severe headaches, drowsiness, and apathy. The skin of a patient acquires a pale tint, dryness is noted in the mouth, children have vomiting and pain in the abdomen. The tonsil swelling becomes obvious, which can lead to the complete closure of the entrance to the pharynx, extends to the soft and hard palate, often also to the nasopharynx, the patient's breathing becomes difficult, the voice often becomes nasal. The plaque quickly spreads to all tissues of the oropharynx. A key sign of the toxic form of diphtheria of the throat is swelling of the subcutaneous tissue in the neck and sometimes the chest, as a result of which the skin acquires a gelatinous consistency. Anterior upper cervical lymph nodes are significantly enlarged and painful.
It takes place against the background of a normal or slightly elevated patient body temperature, intoxication is absent. From the nasal passages can be seen gray-purulent or bloody-purulent discharge. On the wings of the nose, cheeks, forehead and chin appear soak areas, and then dry crusts. Within the patient's nose, membranous raids are noticeable. Pathological process can affect the paranasal sinuses. When the toxic form is observed swelling of the subcutaneous tissue of the cheeks and neck.
Passes as a banal conjunctivitis and is characterized by moderate hyperemia and swelling of the conjunctiva of the eyelid, with a small amount of gray-purulent discharge from the conjunctival sac (catarrhal form). The membranous form is manifested by obvious swelling of the eyelids, the presence of hard-to-remove films of grayish-white color on their conjunctiva. The toxic form is also accompanied by swelling of the fiber around the orbit.
It leads to a prolonged non-healing of any damage to the skin, hyperemia, there is a dirty-gray plaque on the skin, there is a dense infiltration of the surrounding skin.
From microbiology, I know that the causative agent of tetanus Clostridium tetani is a long, thin, movable rod (4-8x3-0.8 microns). It has no capsule. It forms a round spore at the end of the cell, which gives the microbe the appearance of a drumstick. In the body, spores are not formed. It is Gram-positive. It is an obligate anaerob. It grows well on simple nutrient media at an optimum pH of 6.8-7.4 and a temperature of 37°C. On liquid media gives a uniform turbidity with gas formation. In a column of sugar agar, the colonies have the appearance of lumps of cotton; on blood agar, it grows in the form of a thin plaque of interwoven threads resembling spiders, with a zone of hemolysis. It does not ferment carbohydrates, coagulates milk to flakes form with discoloration, slowly liquefies gelatin. It contains O-somatic antigen, common to all types, and H-antigen, a type-specific, according to which tetanus bacilli are divided into 10 serological types.
I know toxin formation from biochemistry. Clostridium tetani secretes a strong exotoxin consisting of tetanospasmin (neurotoxin) and tetanohemolysin. Tetanospasmin (neurotoxin) acts on the nervous system, causing contraction of striated muscles (severe spasticity). Tetanohemolysin causes hemolysis (destruction) of red blood cells.
Tetanus toxin can be obtained by growing the microbe for 10-14 days in a liquid nutrient medium. The tetanus toxin is easily destroyed by heat, light and oxygen. The introduction of the smallest doses of toxin (0.000001 ml) causes the death of a child with the typical symptoms of tetanus.
The most unpleasant thing for people is the resistance of the tetanus bacterium to changes in the external environment, since the tetanus bacterium remains alive in the form of a spore, even in space.
Pathogenesis and clinic
Getting into the wound in the presence of anaerobic conditions, the spores of tetanus sticks settle, germinate in vegetative forms, multiply and secrete exotoxin. The more exotoxin enters the patient's body, the shorter the incubation period. On average, it is 2 weeks.
Toxins from the affected muscle tissue penetrate into the central nervous system through the motor roots of the nerves and through the blood, causing a state of hyperexcitability of striated muscles. The clinical presentation of the disease develops as a descending tetanus.
The earliest symptom is the tension of the masticatory muscles, causing difficulty in opening the patient’s mouth (trisism), tonic contraction of the facial muscles of the face, as a result of which it has the expression of a forced smile. Then the muscles of the neck, trunk, limbs are affected. Often the extensor muscles of the back are reduced more than the flexor, so the patient's body is curved in an arc. The slightest external irritation (noise, movement of air, light) causes an attack of convulsions.
Death occurs from paralysis of the respiratory muscles or the heart.
Immunity. The transferred disease leaves no immunity. Artificial immunization with toxoid creates a long and fairly intense immunity.
A permanent reservoir of tetanus bacillus is the soil, where the germ enters along with the feces of animals and humans.
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