A strong indication of many diseases is muscular weakness. In this case, changes in the muscle cells can be seen through an electron microscope.
Muscular weakness feature is the similarity of changes in cells. At the same time, this symptom is observed at various types of diseases: hereditary, neurologic, endocrine, inflammatory.
The pathology is characterized with the following symptoms:
Lack of ability to put significant efforts;
Lack of muscle strength;
Muscular weakness causes certain disorders in muscular tissues. Fatigue is how a person feels these disorders. At the same time fatigue does not affect muscle cells organelles.
Muscular weakness (myasthenia) is expressed in a significant decrease in muscular strength. This is due to the fact that muscle tissue cannot contract normally. A person is not capable of normal movements, which are provided by muscles at myopathy, muscular dystrophy and myasthenia. Myasthenia is characterized by normal muscular strength, while a person keeps a sedentary lifestyle. The real weakness arises only when it is required to perform any physical activity, for example, to do the cleaning or walk along the street.
From the neurologists’ point of view, the etiology of muscular weakness may be different.
the upper and lower motor neuron system;
neuromuscular connective system;
in the muscular tissues themselves.
In the opinion of neurologists, the main causes of myopathy are the following:
Injury of the spinal cord in the neck area, cerebrospinal horns cell structure injury, and neuromuscular junctions.
I believe that all the changes in muscle cells, observed in the diseases described above, have the same cause - muscle swelling. This pathology contributes to displacement of cell nuclei in a distal direction. In this case, since the mitochondria, which represent the energy source for the muscle fibers, are closely related to the nuclei, they follow them. As a consequence, neurological abnormalities occur in the muscle swelling area.
In the upper motor neuron system, the spinal cord injury in the neck area is directly related to the pressure exerted on it by the vertebral disc. The disc is subject to pressure by the swelled neck muscles. In the lower motor neuron system the cellular structure of the anterior horns of the spinal cord (multiple radiculopathy) is damaged due to the increase in pressure from the intervertebral discs. Swelling of the back muscles shifts the intervertebral discs from its normal position.
In the neuromuscular junction system, at the myasthenia diagnosis, the muscle cells swelling squeezes the nucleus with mitochondria to the cell periphery. As a result, muscle cells do not receive enough energy. In the muscle system itself, muscle swelling presses on the nucleus. The nucleus is forced to “retreat” to the cell periphery, taking mitochondria with it.
The main signs of primary muscular weakness include the following:
Reduced muscle strength.
Difficulty when performing ordinary things: moving around the house, stairs, holding objects, writing, carrying heavy loads.
Problems in talking or chewing.
Clinical signs of primary arm weakness
Neurologists’ opinion - the main causes of permanent muscular arm weakness are various degenerative-dystrophic spinal cord damages caused by compression of the organ.
I believe that the cause of degenerative-dystrophic spinal cord damage is swelling of the muscles of the back, neck and collar zone, which creates pressure on the intervertebral discs, as well as the spinal roots.
Clinical signs of muscular arm weakness
Rapid fatigue even at low loads.
Feeling of limb stiffness after getting up in the morning (during arthritis).
Paresthesia - feeling of “goose bumps”, tingling in the fingertips.
Pain in the upper limbs joints or muscles from time to time or regularly.
Reduced arm movement amplitude.
Elimination of arm muscle swelling
Reduced sensitivity in fingers or hands either in front or in the rear zone.
Impaired hand skin sensitivity, as well as a low temperature of the skin.
Unconscious movements (at central paralysis and brain damage).
Partial muscle atrophy.
Neurologists offer the following explanations: due to compression of the lower cervical spinal nerves weakness in the hands is felt in case of degenerative spine disease, cervical spondylosis, and cervical radiculopathy.
I believe that degenerative spine disease occurs when cervical and spine muscles are swollen, resulting in pressure on the vertebrae bony cells. The result is the inability of bone cells to get rid of accumulated waste within them. Toxins accumulate inside bone cells. In this case, the bone cell and discs between the vertebrae become dry. Cervical muscles become a barrier on the way of lymph moving from the fingertips. Because of this, the muscles of the upper limbs become swollen again, which causes the primary arm muscular weakness.
Muscle cells swelling contributes to primary muscular weakness development at:
Kurshman-Steinert myopathic syndrome – the last stages.
Pseudorheumatism (a disease of connective tissue that simultaneously affects small joints).
Hidebound disease (connective tissue disease affecting the skin, joints, etc.).
Systemic lupus erythematosus or Libmann disease.
Periarteritis nodosa – vasculitis of medium and small size vessels.
Inflammatory process in the arm vessels (Buerger's disease).
Weak and constantly cold hands are observed at Raynaud's syndrome, which causes the increased sensitivity to the cold in upper limbs. Also, painful sensations and weakness in the hands manifest at joint anomalies - arthritis and arthrosis (at arthritis pain occurs in a state of rest, at arthrosis - when a person moves).
I believe that the emergence of the scalenus-anticus syndrome is preceded by muscle tissue swelling. The swelling occurs in the collar muscles region as a result of neuritis. Swelling of the forearm group of muscles leads to wrist Carpal Tunnel Syndrome. In this case, the medial nerve of the carpal tunnel is subject to the pressure of the forearm swollen muscles.
Clinical symptoms of leg muscle weakness
Pain in the joints.
Pain in the muscular tissues of the lower limbs and the pelvic area.
Reduced amplitude of leg movement in varying degrees.
Reduced sensitivity in the foot anterior and posterior regions.
Leg skin sensitivity defect, as well as lowered temperature of the skin cover.
Unconscious body movements.
According to neurologists, degenerative disc disease of the lower back is the cause of a weakness feeling in the lower limbs.
I believe that the root cause of problems with legs muscular weakness is not a spinal injury, but a swelling in the muscles of the back, buttocks and lumbar zone.
Elimination of painful sensations in the lower limbs
Treatment of legs numb feeling
The difference between the primary muscle weakness and asthenia (muscle fatigue, exhaustion)
The main difference between the primary muscle weakness and asthenia is that asthenia causes only sensations of weak muscles and atony. The muscles do not have any damage. Exhaustion can be a symptom of various chronic diseases - sleep disorders, cardiovascular, respiratory, endocrine diseases.
Asthenia can affect both individual organs and entire organ systems. A vivid example is asthenopia, which causes eyesight problems. A person feels discomfort and fast fatigue due to visual load. In this case, the disease is particularly evident when looking at objects from a close distance.
What is the difference between the primary muscle weakness and muscles fatigability?
Muscle fatigue is a sign of myasthenia. According to WHO classification, myasthenia includes: Goldflam disease, Oppenheim disease, laughing sickness, Erb-Goldflam disease.
The main clinical sign of myasthenia is a syndrome of permanent muscle fatigue, accompanied by weakness and pain in the upper and lower limbs, without sensory deprivation. Especially the signs of myasthenia manifest after physical activity, while they relieve during the rest time.
Myasthenia sufferers have one peculiarity - they cannot complete repetitive movements. This is due to the fact that with each effort the muscles become weaker and weaker, which in the end leads to a complete lack of strength. Manifestations of fatigue are visible in everything that a person does. It is difficult for a patient to talk and eat food.
Changes in muscle cells at muscle weakness
Muscular dystrophy is characterized by certain pathomorphological changes: muscles thinning out, replacement of muscular tissue with adipose and connective tissue, and swelling. Focal necrosis zones appear in sarcoplasm, the nuclei of muscle cells are placed in chains, muscle fibers lose their cross-striation.
That's what I saw, looking into the electron microscope - there have been significant changes due to the primary muscle weakness in the cells.
А. A healthy muscle cell consisting of tightly packed polygon fibers with a small amount of intercellular matrix (5%).
В. Patient’s muscle cell affected by primary muscle weakness. Muscle fiber diameters are different, and the content of intercellular material aberrates by 20%. Muscle fibers are partially replaced with adipose and connective tissue. Clusters of nuclei are visible locally in the form of chains. Muscle fibers are longitudinally split and form vacuoles.
Muscle weakness treatment
According to neurologists, the primary muscle weakness cannot be cured. Medicine can only slow the disease progression rate. In order to do this they apply the complex therapy correcting metabolic disorders, diet, and special gymnastics.
Quote: I believe that the primary cause of primary muscle weakness development is protein swelling of the muscle tissues. To treat this disease, I use emendic procedures. They effectively remove swelling. In this case, people regain their strength. They begin to perform physical exertion more easily.
After three procedures, my patient Emine easily sits down and squats. She is able to sit down and stand up six times without any help:
Part of the emendic procedure. Please note that it is impossible to master the method just watching the video!
Improvements in Emine after a number of procedures:
Emine’s gratitude to Dr. Nikonov for his help:
The cost of a written request to the doctor - 800 $
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