Why many procedures are required to restore muscles

Changes in muscle tissues with mild degree of spastic forms of infantile cerebral palsy. Next, this kind of infantile cerebral palsy will be described as spastic: tetraplegia, diplegia, and hemiplegia.

When spasticity lasts for not more than one year, muscle tissues have a slight necrobiotic fiber transformation, as well as a partial loss of uniformity of nuclear distribution around the periphery. In this image you can see such changes:

The next step is the change in the connective membrane around the muscles, which is epimysium. It happens as follows:

• Insignificant coarsening of the structure of the epimysium fibers.
• Thickening of fibers.
• Narrowing of the nuclear perimeter in the equatorial zone.

Mild spasticity is characterized by the presence of a minimum number of sites with muscle fibers without nuclei. In perimysium and epimysium, the vessels of various sizes can be seen.

The gaps between the muscle fibers become loosened, which is due to:

• Swelling.
• Disintegration of muscle fibers.

The disintegration of muscle fibers is confirmed by the presence of sites that simultaneously combine loosening of fibers and denuclearized zones. Loosening of fibers occurs due to disorder in the regulation of metabolic processes (transcription and protein biosynthesis) produced by nuclei.

With a mild spasticity of more than one year, the muscle fibers are characterized by certain morphological changes that can be seen in the photo below:

• The number of fibers in the field of vision with incomplete absence of nuclei in certain sites increases.
• Chaotically located correlations of nuclei are combined with loosened sites.

Usually, the muscle fibers are randomly scattered and have pronounced endomysium interlayers, as well as formed gaps between the fibers. In addition to this, there is a connective tissue cell cluster between the muscle fibers: globocellular and fibroblasts.

In addition, it is worth noting that the number of fat cells between muscle fibers and in perimysium is reduced. On the background of this process, the emergence of vessels with narrowed lumen and thick walls is observed. Hyperchromia and a decrease in the size of the nuclei of muscle cells can also be noted.

Muscles with mild spasticity that lasts up to one year have a minor degree of necrobiotic cell changes with an incomplete loss of uniformity in the distribution of nuclei along the periphery of the fibers.

Changes in muscle tissue with a severe degree of spastic infantile cerebral palsy

The severe degree of spasticity of the child’s muscle fibers for at least one year has morphological changes of the following nature, shown in the photo below:

• Necrobiosis of fibers.
• Disorganization of fibers;
• Presence of sites with anucleate cells.

The image shows changes in the long adductor muscle with severe contracture, which lasts for more than a year.

In certain sites, the disorders of the morphological structure can be seen: there are characteristic places with split and branched fibers, narrowed blood vessels with stagnant blood.

The following changes can usually be seen:

• Loss of normal structure and necrobiotic fibers.
• Pycnosis.
• Absence of nuclei.
• Weakly expressed transversely striated banding and homogeneity of sarcoplasm of muscle cells.

In children with severe spasticity of muscles, significant changes take place in tissues. The higher the spasticity, the more pronounced these changes are, while not only muscle fibers are affected, but also endomysium, perimysium and epimysium.

Fibers of muscles become polymorphic in their thickness. Depending on the degree of contracture, the following changes are observed:

• The number of sites with anucleate cells increases proportionately;
• In the fibers near the anucleate zones, the stratification increases.

It is worth noting that serious transformation takes place in the vascular system during these processes. In the cross section of the muscle fiber, it is seen that the more spastic the muscles, the less vessels remain in them. Having analyzed this information, we can conclude that the long adductor muscle of the thigh with a severe degree of contracture has serious cellular changes. All this suggests that with a severe degree of contracture, significant trophic transformations occur, the structure of cell membranes is disrupted, there is a violation of the homeostasis of the calcium pump inside the cells, which in turn is possibly a consequence of hypoxia and the deficiency of ATP, as well as the cause of contracture.

Conclusion

Restoration of the normal functioning of muscle tissue is possible only in case:

• in the muscle fibers, the nuclei are evenly distributed;
• in mitochondria, the generation of energy for structural proteins occurs completely and in normal mode;
• swelling was eliminated not only from muscle fibers, but also from the interfiber space.

Dr. Nikonov

It is possible to restore the normal movements of the child’s muscles using emendic procedures. I have been developing this recovery method for 30 years. Please note that I am teaching parents how to restore their children independently. The fact is that the necessary number of procedures for restoring the normal functioning of the child’s muscles is in the range from 200 to 1000. These figures are relevant for daily work with the muscles of the child.