Home pageArticlesThe 2017 Nobel Prize winners explained the mechanism of emergence of cerebral palsy
The 2017 Nobel Prize winners explained the mechanism of emergence of cerebral palsy
Only nowadays, the science gradually approaches the understanding of the processes leading to development of cerebral palsy. In 2017, the Noble Prize was awarded to the scientists who discovered molecular mechanisms responsible for recirculation of circadian rhythms. Genetic scientists from America Jeffrey C. Hall, Michael Rosbash and Michael W. Young confirmed the viewpoint of Doctor Nikonov as of formation of swellings in muscle tissues, which he has been already speaking about for more than 30 years.
The discovery made by the scientists consists in that they managed to separate a specific gene controlling the daily biological rhythm. This gene performs coding of protein, which is produced during nighttime, and later is used by a cell during daytime. Besides, the scientists determined additional protein components capable to control the cell’s clockwork mechanisms. The biological rhythm has a particular significance for human life. It exerts influence upon all essential processes in the organism:
The circadian rhythm constitutes a regular organism adaptation to physiologic fluctuations during the day. The disturbance of this rhythm may result in sickness.
While studying the cytoplasm of a muscle cell, the genetic physicians Jeffrey C. Hall, Michael Rosbash and Michael W. Young detected the protein PER (Periode). This is exactly it is produced during nighttime with the help of “Period” gene. During night, the organism remains in a quiet state that makes possible the growth of protein amount. As for the daytime, this component, on the contrary, is consumed actively for various needs and without recovery since its production is blocked by “TIM and DBT” proteins in the nucleus of a muscle cell.
During various pathologies, the muscle tissue protein is produced continuously since the function “TIM and DBT” is impaired. As a consequence, the overabundance of protein is generated that we observe in the form of muscle swelling.
One more the Nobel Prize laureate working in the field of research studies into cell functions is Yoshinori Ohsumi. The award was given to this scientist for the studying swelling in muscle cells. He authored an academic paper on autophagy, which describes the wastes disposal process within a normally functioning cell.
Decay process of old proteins in a muscle cell
Dysfunction of human muscles emerges during malperformances in functioning of the “Period” gene when unnecessary protein substances are accumulated in their cells. In this context, the degree of muscles’ injury in cerebral palsy depends on:
amount of excess protein in muscle tissues;
percentage of invaded cells in a swelling.
Protein boulders inside a muscle cell
In 2013, there were also achieved the excellent results in the area of studies into internal cytoarchitectonics processes. Owing to them, the famous scientists named James E. Rothman, Randy W. Schekman, Thomas C. Südhof won the Nobel Prizes.
The Nobel Prize laureates uncovered the mechanism of vesicular transport, which is the main system of cell exchange. By the agency of this process, the protein travels continuously within different cells in special bubbles-vesicles.
In the above presented picture, a green-colored ball is depicted being a vesicle bubble filled with the protein unnecessary for a cell. It is transported by an orange “homunculus” (transportation protein) moving towards the periphery of muscle tissue.
The protein delivered to the cell boundary is ejected outwards. In case of protein oversaturation, the vesicle bubbles fail to cope with their task. As a consequence, the cell is overfilled gradually.
In the above presented picture, it is shown how the transportation protein relocates a vesicle bubble. This is what happens in the muscle tissues of children suffering from CP.
I began to talk about a protein swelling in human muscles already 20 years ago when contemporary academic persons were making only their first discoveries. I developed the methodology that allows rehabilitation of a muscle cell up to the sound status in children suffering from cerebral palsy.
Egor is the first patient whom I managed to render assistance to. Nowadays, it is possible to make video reports by means of smart phones, therefore, I try to record the treatment procedures as often as possible.
Here you can see how a premature infant with his weight of only 730 g was rehabilitated:
Bogdan in his 3 years of age:
More videos worthwhile to be seen:
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